| Fighter | Record | Last Bout |
|---|---|---|
| Manoel Sousa | 15-1-0 | 2026-08-08 |
| Marina Spasic | 7-2-0 | 2026-08-01 |
| Matt Schnell | 17-11-0 (1 NC) | 2026-06-06 |
| Matthew Semelsberger | 11-8-0 | 2024-11-09 |
| Mayra Bueno Silva | 10-7-1 (1 NC) | 2026-04-25 |
| Muhammad Saidov | 10-0-0 | 2026-07-25 |
| Muslim Salikhov | 22-6-0 | 2026-09-12 |
| Natalia Silva | 20-5-1 | 2026-10-03 |
| Navajo Stirling | 11-0-0 | 2026-08-01 |
| Nazim Sadykhov | 11-3-1 | 2026-06-27 |
| Ollie Schmid | 4-3-0 | 2026-05-02 |
| Oumar Sy | 12-3-0 | 2026-09-05 |
| Ovince Saint Preux | 27-18-0 | 2024-10-05 |
| Pat Sabatini | 22-5-0 | 2026-05-09 |
| Punahele Soriano | 13-5-0 | 2026-09-05 |
| Quillan Salkilld | 13-1-0 | 2026-08-08 |
| Rayanne dos Santos | 14-9-0 | 2025-05-31 |
| Ricky Simon | 22-7-1 | 2026-09-26 |
| Roberto Soldic | 21-4-0 | 2026-10-03 |
| Rodrigo Sezinando | 9-2-0 | 2025-09-13 |
| Ryan Spann | 24-12-0 | 2026-09-05 |
| Said Nurmagomedov | 18-5-0 | 2025-07-26 |
| Saimon Oliveira | 18-7-0 | 2025-10-11 |
| Salahdine Parnasse | 24-2-0 | 2026-09-05 |
| Sam Hughes | 11-7-0 | 2026-03-14 |
| Sam Patterson | 15-3-1 | 2026-07-25 |
| Sangwook Kim | 13-4-0 | 2026-01-31 |
| Santiago Luna | 8-1-0 | 2026-06-06 |
| Santiago Ponzinibbio | 31-10-0 | 2026-07-25 |
| Saygid Izagakhmaev | 22-4-0 | 2026-07-25 |
| Sean Brady | 19-2-0 | 2026-11-07 |
| Sean King III | 6-0-0 | 2026-09-12 |
| Sean O'Malley | 20-3-0 (1 NC) | 2026-06-14 |
| Sean Sharaf | 4-2-0 | 2026-09-19 |
| Sean Strickland | 31-7-0 | 2026-05-09 |
| Sean Woodson | 14-2-1 | 2026-08-29 |
| Sebastian Szalay | 10-2-0 | 2026-01-31 |
| Sedriques Dumas | 10-5-0 (1 NC) | 2026-04-25 |
| Seokhyeon Ko | 13-3-0 | 2026-07-18 |
| Sergei Pavlovich | 21-3-0 | 2026-05-30 |
| Serghei Spivac | 18-7-0 | 2026-08-22 |
| Serhiy Sidey | 12-2-0 | 2025-05-03 |
| SeungWoo Choi | 11-8-0 | 2025-03-15 |
| Shamil Gaziev | 15-3-0 | 2026-08-22 |
| Shane Collins | 8-0-0 | 2026-06-20 |
| Shanelle Dyer | 8-1-0 | 2026-08-22 |
| Shara Magomedov | 17-1-0 | 2026-06-27 |
| Shauna Bannon | 7-3-0 | 2026-05-16 |
| Shavkat Rakhmonov | 19-0-0 | 2024-12-07 |
| Shem Rock | 12-3-1 | 2026-03-21 |