| Fighter | Record | Last Bout |
|---|---|---|
| Sean O'Malley | 20-3-0 (1 NC) | 2026-06-14 |
| Sean Sharaf | 4-2-0 | 2026-09-19 |
| Sean Strickland | 31-7-0 | 2026-05-09 |
| Sean Woodson | 14-2-1 | 2026-08-29 |
| Sebastian Szalay | 10-2-0 | 2026-01-31 |
| Sedriques Dumas | 10-5-0 (1 NC) | 2026-04-25 |
| Seokhyeon Ko | 13-3-0 | 2026-07-18 |
| Sergei Pavlovich | 21-3-0 | 2026-05-30 |
| Serghei Spivac | 18-7-0 | 2026-08-22 |
| Serhiy Sidey | 12-2-0 | 2025-05-03 |
| SeungWoo Choi | 11-8-0 | 2025-03-15 |
| Shamil Gaziev | 15-3-0 | 2026-08-22 |
| Shane Collins | 8-0-0 | 2026-06-20 |
| Shanelle Dyer | 8-1-0 | 2026-08-22 |
| Shara Magomedov | 17-1-0 | 2026-06-27 |
| Shauna Bannon | 7-3-0 | 2026-05-16 |
| Shavkat Rakhmonov | 19-0-0 | 2024-12-07 |
| Shem Rock | 12-3-1 | 2026-03-21 |
| Shi Ming | 18-6-0 | 2024-11-23 |
| Sodiq Yusuff | 13-5-0 | 2025-05-17 |
| Sofia Montenegro | 6-3-0 | 2026-09-05 |
| Song Kenan | 22-9-0 | 2024-11-23 |
| Song Yadong | 24-9-1 (1 NC) | 2026-08-29 |
| Stan Dorsainvil | 6-0-0 | 2026-08-22 |
| Stephanie Luciano | 8-2-1 | 2026-08-01 |
| Stephen Thompson | 17-9-1 | 2025-07-12 |
| Steve Erceg | 14-5-0 | 2026-07-25 |
| Steve Garcia | 19-6-0 | 2026-06-14 |
| Steven Asplund | 8-2-0 | 2026-08-08 |
| Steven Koslow | 6-1-0 | 2026-10-17 |
| Steven Nguyen | 10-2-0 | 2025-07-26 |
| Stewart Nicoll | 8-4-0 | 2026-07-18 |
| Stipe Miocic | 20-5-0 | 2024-11-16 |
| Sulangrangbo | 10-4-0 | 2026-01-31 |
| Sumudaerji | 20-7-0 (1 NC) | 2026-08-29 |
| SuYoung You | 16-4-0 (2 NC) | 2026-03-14 |
| Tabatha Ricci | 12-5-0 | 2026-07-18 |
| Tagir Ulanbekov | 17-3-0 | 2025-11-22 |
| Tahir Abdullayev | 20-3-0 | 2026-06-27 |
| Tai Tuivasa | 15-10-0 | 2026-09-19 |
| Tainara Lisboa | 7-4-0 | 2026-10-31 |
| Taiyilake Nueraji | 12-1-0 (1 NC) | 2025-08-23 |
| Talita Alencar | 8-1-1 | 2026-04-25 |
| Tallison Teixeira | 9-2-0 | 2026-05-30 |
| Tamires Vidal | 7-4-0 | 2024-10-19 |
| Tanner Boser | 22-11-1 | 2026-10-17 |
| Tatiana Suarez | 13-1-0 | 2026-04-11 |
| Tatsuro Taira | 18-2-0 | 2026-05-09 |
| Taylor Lapilus | 21-4-0 | 2024-09-28 |
| Tecia Pennington | 15-8-0 | 2025-11-08 |