| Fighter | Record | Last Bout |
|---|---|---|
| Frank Hamaker | 1-0-0 | 1994-03-11 |
| Frank Lester | 11-6-0 (1 NC) | 2009-06-20 |
| Frank Mir | 18-11-0 | 2016-03-19 |
| Frank Shamrock | 23-10-2 | 1999-09-24 |
| Frank Trigg | 21-9-0 | 2010-02-06 |
| Frankie Edgar | 23-11-1 | 2022-11-12 |
| Frankie Perez | 10-4-0 | 2017-07-22 |
| Frankie Saenz | 13-7-0 | 2020-08-01 |
| Fred Ettish | 1-1-0 | 1994-03-11 |
| Fredson Paixao | 10-5-0 (1 NC) | 2010-12-04 |
| Fredy Serrano | 3-2-0 | 2016-12-17 |
| Geraldo de Freitas | 12-6-0 | 2020-11-14 |
| Glaico Franca Moreira | 15-5-0 | 2016-09-24 |
| Hermes Franca | 24-17-0 (1 NC) | 2009-09-19 |
| Ian Freeman | 20-7-1 | 2003-06-06 |
| Jason Fairn | 4-5-0 | 1994-12-16 |
| Jason Von Flue | 14-12-1 | 2006-08-17 |
| Jesse Forbes | 15-5-0 | 2010-05-29 |
| Jinh Yu Frey | 11-10-0 | 2023-10-21 |
| Jon Fitch | 30-7-1 (1 NC) | 2013-02-02 |
| Josh Ferguson | 10-5-0 | 2012-07-11 |
| Josh Fremd | 11-6-0 | 2024-07-13 |
| Jussier Formiga | 23-8-0 | 2020-06-06 |
| Justin Frazier | 10-3-0 | 2018-11-30 |
| Kalindra Faria | 18-8-1 | 2018-08-25 |
| Katsuhisa Fujii | 9-18-1 | 1999-11-19 |
| Kelly Faszholz | 4-2-0 | 2016-10-01 |
| Kenny Florian | 14-6-0 | 2011-10-08 |
| Kevin Ferguson | 5-2-0 (1 NC) | 2010-05-08 |
| Luigi Fioravanti | 26-15-0 | 2009-02-07 |
| Maiquel Falcao | 37-10-0 (1 NC) | 2010-11-20 |
| Marcel Fortuna | 9-3-0 | 2017-11-11 |
| Masio Fullen | 11-7-0 | 2016-01-30 |
| Melinda Fabian | 4-4-2 | 2018-06-23 |
| Michal Figlak | 8-2-0 | 2024-04-27 |
| Mirko Filipovic | 35-11-2 (1 NC) | 2015-04-11 |
| Nick Fiore | 6-2-0 | 2023-05-20 |
| Paul Felder | 17-6-0 | 2020-11-14 |
| Philip De Fries | 12-6-0 (1 NC) | 2013-04-06 |
| Renee Forte | 8-4-0 | 2014-03-15 |
| Ricardo Funch | 9-6-0 | 2012-06-22 |
| Rich Franklin | 29-7-0 (1 NC) | 2012-11-10 |
| Riki Fukuda | 24-9-0 (1 NC) | 2013-03-02 |
| Ron Faircloth | 33-20-0 (1 NC) | 2005-10-07 |
| Sam Fulton | 0-2-0 | 1997-07-27 |
| Sarah Frota | 9-2-0 | 2019-07-27 |
| Scott Ferrozzo | 4-2-0 | 1997-02-07 |
| Scott Fiedler | 0-1-0 | 1996-07-12 |
| Spencer Fisher | 24-9-0 | 2012-06-22 |
| Tony Ferguson | 26-11-0 | 2024-08-03 |