| Fighter | Record | Last Bout |
|---|---|---|
| Chris Spang | 6-3-0 | 2013-04-06 |
| Claudio Silva | 14-4-0 | 2022-07-23 |
| Clifford Starks | 13-3-0 | 2013-04-20 |
| Cody Stamann | 21-8-1 | 2024-11-09 |
| Cole Smith | 7-2-0 | 2020-09-05 |
| Colton Smith | 7-4-0 | 2014-06-28 |
| Cory Sandhagen | 18-7-0 | 2026-07-11 |
| Cristina Stanciu | 5-2-0 | 2016-07-13 |
| Cub Swanson | 31-14-0 | 2026-04-11 |
| Curtis Stout | 11-12-1 | 2004-06-19 |
| Damian Stasiak | 10-6-0 | 2018-07-22 |
| Dan Severn | 101-19-1 | 2000-09-22 |
| Dan Stittgen | 12-5-0 | 2012-07-11 |
| Daniel Santos | 14-3-0 | 2026-05-16 |
| Daniel Sarafian | 10-6-0 | 2016-02-21 |
| Daniel Spitz | 6-3-0 | 2019-10-18 |
| Daniel Spohn | 15-6-0 | 2014-07-06 |
| Danny Silva | 11-2-0 | 2026-03-21 |
| Darko Stosic | 13-4-0 | 2020-01-25 |
| Darren Stewart | 12-8-0 (2 NC) | 2021-08-28 |
| Darrill Schoonover | 14-8-0 | 2009-12-05 |
| Dave Strasser | 25-8-0 | 2003-09-26 |
| Denis Stojnic | 13-3-0 (1 NC) | 2009-06-13 |
| Dennis Siver | 23-11-0 (1 NC) | 2017-06-25 |
| Devonte Smith | 11-4-0 | 2022-03-05 |
| Diego Sanchez | 31-13-0 | 2020-09-26 |
| Diego Saraiva | 22-20-1 | 2007-09-22 |
| Djorden Santos | 11-3-0 | 2026-09-12 |
| Dmitri Stepanov | 0-1-0 | 1997-05-30 |
| Dmitrii Smoliakov | 9-3-0 | 2019-04-27 |
| Dmitry Sosnovskiy | 11-0-0 | 2018-03-17 |
| Dominique Steele | 14-9-0 | 2017-06-10 |
| Don Shainis | 12-5-0 | 2023-02-11 |
| Douglas Silva de Andrade | 29-7-0 (1 NC) | 2026-02-28 |
| Duda Santana | 3-1-0 | 2019-06-01 |
| Dustin Stoltzfus | 17-8-0 | 2026-08-15 |
| Eddie Sanchez | 15-8-0 | 2008-12-10 |
| Edimilson Souza | 15-5-0 | 2015-11-07 |
| Edmen Shahbazyan | 16-6-0 | 2026-09-19 |
| Elias Silverio | 13-3-0 | 2015-08-23 |
| Elijah Smith | 10-1-0 | 2026-03-14 |
| Elizeu Zaleski dos Santos | 25-10-1 | 2025-08-02 |
| Elvis Sinosic | 7-11-2 | 2007-04-21 |
| Eric Schafer | 14-8-2 | 2012-01-20 |
| Eric Shelton | 12-6-0 | 2019-03-23 |
| Eric Spicely | 12-6-0 | 2019-06-22 |
| Erick Silva | 19-9-0 (1 NC) | 2017-12-16 |
| Erik Silva | 9-4-0 | 2026-02-28 |
| Fabia Sintes | 12-3-0 | 2026-09-05 |
| Fabiano Scherner | 11-10-0 (3 NC) | 2006-05-27 |