| Fighter | Record | Last Bout |
|---|---|---|
| Alberto Uda | 12-2-0 | 2016-08-20 |
| Caol Uno | 33-19-5 | 2010-03-31 |
| Carlos Ulberg | 15-1-0 | 2026-04-11 |
| Darren Uyenoyama | 10-6-0 | 2013-12-14 |
| Gasan Umalatov | 17-4-2 | 2015-11-07 |
| Gilbert Urbina | 8-5-0 | 2026-10-17 |
| Hector Urbina | 17-10-1 | 2016-09-24 |
| Ilimbek Akylbek Uulu | 10-3-0 | 2026-09-26 |
| Kamaru Usman | 21-5-0 | 2026-07-18 |
| Mohammed Usman | 12-4-0 | 2025-06-21 |
| Tagir Ulanbekov | 17-3-0 | 2025-11-22 |
| Ulysses Gomez | 9-5-0 | 2013-02-16 |
| Umar Nurmagomedov | 20-2-0 | 2026-08-29 |
| Uran Satybaldiev | 9-1-0 | 2025-08-23 |
| Uriah Hall | 18-11-0 | 2022-07-02 |
| Urijah Faber | 35-11-0 | 2019-12-14 |
| Uros Medic | 14-3-0 | 2026-08-01 |
| Yasuhiro Urushitani | 21-8-6 | 2012-11-10 |
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