| Fighter | Record | Last Bout |
|---|---|---|
| Daniel Spitz | 6-3-0 | 2019-10-18 |
| Daniel Spohn | 15-6-0 | 2014-07-06 |
| Darko Stosic | 13-4-0 | 2020-01-25 |
| Darren Stewart | 12-8-0 (2 NC) | 2021-08-28 |
| Darrill Schoonover | 14-8-0 | 2009-12-05 |
| Dave Strasser | 25-8-0 | 2003-09-26 |
| Denis Stojnic | 13-3-0 (1 NC) | 2009-06-13 |
| Dennis Siver | 23-11-0 (1 NC) | 2017-06-25 |
| Devonte Smith | 11-4-0 | 2022-03-05 |
| Diego Sanchez | 31-13-0 | 2020-09-26 |
| Diego Saraiva | 22-20-1 | 2007-09-22 |
| Dmitri Stepanov | 0-1-0 | 1997-05-30 |
| Dmitrii Smoliakov | 9-3-0 | 2019-04-27 |
| Dmitry Sosnovskiy | 11-0-0 | 2018-03-17 |
| Dominique Steele | 14-9-0 | 2017-06-10 |
| Don Shainis | 12-5-0 | 2023-02-11 |
| Duda Santana | 3-1-0 | 2019-06-01 |
| Eddie Sanchez | 15-8-0 | 2008-12-10 |
| Edimilson Souza | 15-5-0 | 2015-11-07 |
| Elias Silverio | 13-3-0 | 2015-08-23 |
| Elvis Sinosic | 7-11-2 | 2007-04-21 |
| Eric Schafer | 14-8-2 | 2012-01-20 |
| Eric Shelton | 12-6-0 | 2019-03-23 |
| Eric Spicely | 12-6-0 | 2019-06-22 |
| Erick Silva | 19-9-0 (1 NC) | 2017-12-16 |
| Fabiano Scherner | 11-10-0 (3 NC) | 2006-05-27 |
| Felicia Spencer | 9-3-0 | 2021-11-13 |
| Felipe Silva | 8-2-0 | 2018-05-19 |
| Floyd Sword | 12-3-0 | 2007-06-23 |
| Frank Shamrock | 23-10-2 | 1999-09-24 |
| Frankie Saenz | 13-7-0 | 2020-08-01 |
| Fredy Serrano | 3-2-0 | 2016-12-17 |
| Gabriel Silva | 8-2-0 | 2020-02-29 |
| Genki Sudo | 15-4-2 | 2004-04-02 |
| George Sotiropoulos | 14-7-0 | 2013-10-19 |
| George Sullivan | 17-7-0 (1 NC) | 2018-08-25 |
| Georges St-Pierre | 26-2-0 | 2017-11-04 |
| Gerald Strebendt | 9-7-0 | 2003-09-26 |
| Gilbert Smith | 12-6-0 | 2013-04-13 |
| Gokhan Saki | 1-2-0 | 2018-07-07 |
| Greg Soto | 9-4-0 | 2011-01-01 |
| Greg Stott | 0-1-0 | 1997-10-17 |
| Hans Stringer | 22-8-3 | 2015-07-18 |
| Hayato Sakurai | 38-13-2 | 2002-03-22 |
| Hector Sandoval | 14-4-0 | 2017-08-05 |
| Henrique da Silva | 14-5-0 | 2017-09-22 |
| Igor Severino | 8-1-0 | 2024-03-23 |
| Iliarde Santos | 30-13-1 (1 NC) | 2013-10-09 |
| Ivan Salaverry | 14-9-0 | 2008-05-24 |
| Ivan Serati | 12-4-0 | 2009-01-17 |