| Fighter | Record | Last Bout |
|---|---|---|
| Shannon Ross | 13-9-0 | 2023-12-09 |
| Shara Magomedov | 17-1-0 | 2026-06-27 |
| Shauna Bannon | 7-3-0 | 2026-05-16 |
| Shavkat Rakhmonov | 19-0-0 | 2024-12-07 |
| Shawn Jordan | 19-8-0 | 2015-10-03 |
| Shayilan Nuerdanbieke | 39-12-0 | 2024-06-15 |
| Shayna Baszler | 15-11-0 | 2015-03-21 |
| Sheila Gaff | 9-7-0 | 2013-08-03 |
| Sheldon Westcott | 10-3-1 | 2016-01-02 |
| Shem Rock | 12-3-1 | 2026-03-21 |
| Sherman Pendergarst | 11-18-0 (1 NC) | 2006-11-18 |
| Sheymon Moraes | 11-4-0 | 2019-07-13 |
| Shi Ming | 18-6-0 | 2024-11-23 |
| Shinsho Anzai | 10-3-0 | 2018-06-23 |
| Shonie Carter | 51-31-7 (1 NC) | 2006-12-13 |
| Shunichi Shimizu | 30-18-11 (1 NC) | 2014-01-04 |
| Sijara Eubanks | 8-7-0 | 2021-12-18 |
| Silvana Gomez Juarez | 11-5-0 | 2022-11-12 |
| Simeon Thoresen | 17-6-1 | 2013-01-26 |
| Sione Latu | 1-0-0 | 1999-03-05 |
| Sirwan Kakai | 12-5-0 | 2015-08-08 |
| Siyar Bahadurzada | 24-8-1 | 2019-09-28 |
| Soa Palelei | 22-5-0 | 2015-08-01 |
| Sodiq Yusuff | 13-5-0 | 2025-05-17 |
| Sofia Montenegro | 6-3-0 | 2026-09-05 |
| Solomon Hutcherson | 11-7-0 (1 NC) | 2006-06-24 |
| Song Kenan | 22-9-0 | 2024-11-23 |
| Song Yadong | 24-9-1 (1 NC) | 2026-08-29 |
| Spencer Fisher | 24-9-0 | 2012-06-22 |
| Spike Carlyle | 9-3-0 | 2020-11-28 |
| Stan Dorsainvil | 6-0-0 | 2026-08-22 |
| Stanislav Nedkov | 12-2-0 (1 NC) | 2015-01-24 |
| Stefan Sekulic | 12-4-0 | 2021-04-24 |
| Stefan Struve | 33-13-0 | 2020-10-24 |
| Stephan Bonnar | 15-9-0 | 2012-10-13 |
| Stephanie Egger | 8-5-0 | 2023-12-09 |
| Stephanie Luciano | 8-2-1 | 2026-08-01 |
| Stephen Bass | 11-2-0 | 2011-12-03 |
| Stephen Thompson | 17-9-1 | 2025-07-12 |
| Steve Berger | 21-23-2 (1 NC) | 2002-06-22 |
| Steve Bosse | 12-2-0 | 2016-06-18 |
| Steve Bruno | 15-6-0 | 2009-02-07 |
| Steve Byrnes | 6-1-0 | 2006-12-13 |
| Steve Cantwell | 7-6-0 | 2012-02-25 |
| Steve Erceg | 14-5-0 | 2026-07-25 |
| Steve Garcia | 19-6-0 | 2026-06-14 |
| Steve Jennum | 2-3-0 | 1995-12-16 |
| Steve Judson | 0-2-0 | 2000-03-10 |
| Steve Kennedy | 24-8-0 | 2015-11-14 |
| Steve Lopez | 13-6-1 | 2010-09-25 |