| Fighter | Record | Last Bout |
|---|---|---|
| Scott Holtzman | 14-6-0 | 2022-12-03 |
| Scott Jorgensen | 15-12-0 | 2015-11-21 |
| Scott Junk | 8-3-1 (1 NC) | 2007-09-22 |
| Scott Morris | 2-1-0 | 1994-03-11 |
| Scott Smith | 18-11-0 (1 NC) | 2007-06-16 |
| Sean Alvarez | 4-3-0 | 2003-04-25 |
| Sean Daugherty | 0-2-0 | 1994-03-11 |
| Sean Gannon | 2-1-0 | 2005-10-07 |
| Sean McCorkle | 17-7-0 | 2011-03-26 |
| Sean O'Connell | 17-9-0 | 2016-12-09 |
| Sean Pierson | 14-6-0 | 2013-06-15 |
| Sean Salmon | 18-21-0 | 2007-05-26 |
| Sean Sherk | 36-4-1 | 2010-09-25 |
| Sean Soriano | 14-8-0 | 2021-11-20 |
| Sean Spencer | 12-6-0 | 2016-09-10 |
| Semmy Schilt | 26-14-1 | 2001-06-29 |
| Seo Hee Ham | 17-8-0 | 2016-11-26 |
| Sergey Khandozhko | 28-6-1 | 2022-04-23 |
| Sergey Morozov | 19-5-0 | 2022-12-17 |
| Sergio Moraes | 14-6-1 | 2019-11-16 |
| Sergio Pettis | 18-5-0 | 2019-09-21 |
| Seth Baczynski | 20-14-0 | 2015-04-11 |
| Seth Petruzelli | 14-8-0 | 2010-11-13 |
| SeungGuk Choi | 7-3-0 | 2023-02-04 |
| Shamar Bailey | 16-11-0 | 2011-11-19 |
| Shamil Abdurakhimov | 20-8-0 | 2023-01-21 |
| Shamil Gamzatov | 14-1-0 | 2021-10-30 |
| Shana Dobson | 4-5-0 | 2021-02-20 |
| Shane Burgos | 15-3-0 | 2022-07-16 |
| Shane Campbell | 14-6-0 | 2016-08-27 |
| Shane Carwin | 12-2-0 | 2011-06-11 |
| Shane del Rosario | 11-2-0 | 2012-12-15 |
| Shane Howell | 13-10-0 | 2015-01-18 |
| Shane Nelson | 16-7-0 | 2009-12-12 |
| Shane Primm | 5-5-0 | 2008-12-13 |
| Shane Roller | 11-7-0 | 2012-10-05 |
| Shane Young | 13-8-0 | 2023-09-09 |
| Shanna Young | 9-6-0 | 2022-11-05 |
| Shannon Gugerty | 15-7-0 | 2010-03-21 |
| Shannon Ross | 13-9-0 | 2023-12-09 |
| Shawn Jordan | 19-8-0 | 2015-10-03 |
| Shayilan Nuerdanbieke | 39-12-0 | 2024-06-15 |
| Shayna Baszler | 15-11-0 | 2015-03-21 |
| Sheila Gaff | 9-7-0 | 2013-08-03 |
| Sheldon Westcott | 10-3-1 | 2016-01-02 |
| Sherman Pendergarst | 11-18-0 (1 NC) | 2006-11-18 |
| Sheymon Moraes | 11-4-0 | 2019-07-13 |
| Shinsho Anzai | 10-3-0 | 2018-06-23 |
| Shonie Carter | 51-31-7 (1 NC) | 2006-12-13 |
| Shunichi Shimizu | 30-18-11 (1 NC) | 2014-01-04 |